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KMID : 1007520140230051653
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Food Science and Biotechnology
2014 Volume.23 No. 5 p.1653 ~ p.1659
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Increased Resistance to Stress and an Anti-aging Effect due to Acanthopanax sessiliflorus Roots in Caenorhabditis elegans
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Kim Chul-Kyu
Park Jin-Kook
Lee Jin-Sun
Park Sang-Kyu
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Abstract
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Acanthopanax sessiliflorus, a plant mainly found in Korea, Japan, and China, has been used as a traditional medicine due to the bioactivities of some plant compounds. The antioxidant activity of A. sessiliflorus root in vivo and the anti-aging effect using Caenorhabditis elegans were studied. Pre-treatment with an A. sessiliflorus root extract significantly (p<0.05) increased resistance to oxidative stress and induced increased survival after heat shock and ultraviolet irradiation treatment, compared with controls. A lifespan assay revealed that both the mean and maximum lifespans were significantly (p<0.05) extended due to A. sessiliflorus root extracts, compared with controls. The lifespan extension was not accompanied by reduced reproduction, unlike other long-lived mutants. A. sessiliflorus root extracts also protected worms against human β- amyloid-induced toxicity. A. sessiliflorus root extracts can confer increased resistance to environmental stresses and modulate the aging process in C. elegans.
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KEYWORD
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Acanthopanax sessiliflorus, Caenorhabditis elegans, stress response, lifespan, fertility
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